abstract：OBJECTIVE:We examined the association between different adiposity indices and pulmonary function in Chinese adults in the Guangzhou Biobank Cohort Study (GBCS). METHODS:Participants with body mass index (BMI) < 18.5 (underweight) were excluded. Adiposity indices including BMI, waist circumference (WC), waist hip ratio...

journal_title：Respiratory medicine

authors： Pan J,Xu L,Lam TH,Jiang CQ,Zhang WS,Jin YL,Zhu F,Zhu T,Thomas GN,Cheng KK,Adab P

更新日期：2017-11-01 00:00:00

abstract：INTRODUCTION:The aim was to investigate temporal variation in Health-Related Quality of Life (HRQL) and factors influencing low HRQL, in patients with asthma. MATERIAL AND METHODS:Questionnaire data on patient characteristics and the mini-Asthma Quality of Life Questionnaire (mini-AQLQ) scores from two separate cohort...

journal_title：Respiratory medicine

authors： Sundh J,Wireklint P,Hasselgren M,Montgomery S,Ställberg B,Lisspers K,Janson C

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Non-invasive ventilation (NIV) is increasingly used in the treatment of patients with chronic hypercapnic respiratory failure (CRF). Residual sleep related respiratory events under NIV such as obstructive or central apnea/hypopnea (AH), or patient-ventilator asynchrony (PVA), may compromise treatment efficac...

journal_title：Respiratory medicine

authors： Aarrestad S,Qvarfort M,Kleiven AL,Tollefsen E,Skjønsberg OH,Janssens JP

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:We conducted a randomised controlled trial to assess the effects of daily breathing pattern changes to stable patients with COPD excluding the confounding factors of inspiratory muscle mobilization, by ensuring the load intensities of two inspiratory training devices were equal. PATIENTS AND METHODS:Sixty pati...

journal_title：Respiratory medicine

authors： Wu W,Guan L,Zhang X,Li X,Yang Y,Guo B,Ou Y,Lin L,Zhou L,Chen R

更新日期：2017-11-01 00:00:00

abstract：INTRODUCTION:The World Trade Center (WTC) disaster released a huge quantity and variety of toxicants into the environment. To-date, studies from each of the three major cohorts of WTC-exposed workers have suggested "greater than expected" numbers of post-9/11 cases in some workers. We undertook this study to estimate t...

journal_title：Respiratory medicine

authors： Webber MP,Yip J,Zeig-Owens R,Moir W,Ungprasert P,Crowson CS,Hall CB,Jaber N,Weiden MD,Matteson EL,Prezant DJ

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Inappropriate use of short-acting beta-agonists (SABA) has been associated with increased morbidity and mortality in asthma. However, the extent and pattern of SABA use have changed significantly over recent years. The outcomes in patients who are contemporarily receiving inappropriate doses of SABA have not...

journal_title：Respiratory medicine

authors： FitzGerald JM,Tavakoli H,Lynd LD,Al Efraij K,Sadatsafavi M

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Decreased lung function has health impacts beyond diagnosable lung disease. It is therefore important to understand the factors that may influence even small changes in lung function including obesity, physical fitness and physical activity. The aim of this study was to determine the anthropometric measure m...

journal_title：Respiratory medicine

authors： Rowe A,Hernandez P,Kuhle S,Kirkland S

更新日期：2017-10-01 00:00:00

abstract：BACKGOUND AND OBJECTIVES:The disadvantages of custom-made mandibular advancement devices (MAD) for obstructive sleep apnoea (OSA) therapy are the cost and delay required to manufacture the device. This study aimed to evaluate the efficacy of a titrable, thermoplastic MAD compared to a custom-made MAD for OSA therapy. ...

journal_title：Respiratory medicine

authors： Gagnadoux F,Nguyen XL,Le Vaillant M,Priou P,Meslier N,Eberlein A,Kun-Darbois JD,Chaufton C,Villiers B,Levy M,Trzépizur W,Launois S

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:The current literature suggests a relationship between obstructive sleep apnea (OSA) severity and hematocrit. However, the degree that OSA contributes to clinically significant erythrocytosis is uncertain. The aim of this study is to evaluate this association in a large study sample controlling for multiple ...

journal_title：Respiratory medicine

authors： Nguyen CD,Holty JC

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Reduction in 30-day readmission rate after chronic obstructive pulmonary disease (COPD)-related hospitalization is a national objective. However, little is known about trends in readmission rates in recent years, particularly in priority populations defined by the Agency for Healthcare Research and Quality (...

journal_title：Respiratory medicine

authors： Goto T,Faridi MK,Gibo K,Toh S,Hanania NA,Camargo CA Jr,Hasegawa K

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVE:To determine the characteristics of persons with cognitive impairment being able to self-manage in chronic obstructive pulmonary disease (COPD). METHODS:In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidance this systematic review examined all studies in E...

journal_title：Respiratory medicine

authors： Baird C,Lovell J,Johnson M,Shiell K,Ibrahim JE

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:The ability to exercise is an important clinical outcome in COPD, and the improvement in exercise capacity is recognized to be an important goal in the management of COPD. Therefore, since the current interest in the use of bronchodilators in COPD is gradually shifting towards the dual bronchodilation, we ca...

journal_title：Respiratory medicine

authors： Calzetta L,Ora J,Cavalli F,Rogliani P,O'Donnell DE,Cazzola M

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Interleukin-32(IL-32)γ is a pro-inflammatory cytokine involved in the development and severity of chronic inflammatory diseases, but its role in asthma is unclear. OBJECTIVE:This study was conducted to evaluate the relationship of IL-32γ levels in sputum with the severity of asthma. METHODS:IL-32γ levels i...

journal_title：Respiratory medicine

authors： Kwon JW,Chang HS,Heo JS,Bae DJ,Lee JU,Jung CA,Son JH,Park JS,Kim SH,Min KU,Park CS

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Although the prevalence of chronic obstructive pulmonary disease (COPD) increases with age, no specific therapeutic approaches are available till date for the elderly population. AIM:To assess the efficacy and safety of once-daily indacaterol 150 and 300 μg in elderly patients with moderate to severe COPD. ...

journal_title：Respiratory medicine

authors： Girodet PO,Jasnot JY,Le Gros V,Decuypère L,Cao W,Devouassoux G

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Pneumonia is a leading cause of morbidity and mortality in children worldwide; however, its diagnosis can be challenging, especially in settings where skilled clinicians or standard imaging are unavailable. We sought to determine the diagnostic accuracy of lung ultrasound when compared to radiographically-co...

journal_title：Respiratory medicine

authors： Ellington LE,Gilman RH,Chavez MA,Pervaiz F,Marin-Concha J,Compen-Chang P,Riedel S,Rodriguez SJ,Gaydos C,Hardick J,Tielsch JM,Steinhoff M,Benson J,May EA,Figueroa-Quintanilla D,Checkley W,Lung Ultrasound for Pneumonia Asse

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:The need for additional research on symptomatic smokers with normal spirometry has been recently emphasized. Albeit not meeting criteria for Chronic obstructive pulmonary disease (COPD) diagnosis, symptomatic smokers may experience activity limitation, evidence of airway disease, and exacerbations. We, there...

journal_title：Respiratory medicine

authors： Di Marco F,Terraneo S,Job S,Rinaldo RF,Sferrazza Papa GF,Roggi MA,Santus P,Centanni S

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:Small fiber neuropathy commonly affects patients with sarcoidosis and is often refractory to standard immunosuppressive therapies used for systemic disease. The clinical features of sarcoidosis-associated small fiber neuropathy (SSFN) and its response to medical therapy have not been described in a large popu...

journal_title：Respiratory medicine

authors： Tavee JO,Karwa K,Ahmed Z,Thompson N,Parambil J,Culver DA

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:Interstitial lung disease is a common extra-articular manifestation of rheumatoid arthritis (RA-ILD) and is associated with significant morbidity and mortality. However, limited data exist regarding predictors of mortality. We sought to examine the prognostic value of the high-resolution computed tomography (HR...

journal_title：Respiratory medicine

authors： Yunt ZX,Chung JH,Hobbs S,Fernandez-Perez ER,Olson AL,Huie TJ,Keith RC,Janssen WJ,Goldstein BL,Lynch DA,Brown KK,Swigris JJ,Solomon JJ

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Holding chambers or spacers can enhance the efficacy of pressurized metered dose inhalers (pMDI) in delivering inhaled medications, as they reduce the need for hand-breath coordination and improve lower airways deposition. Nevertheless, their cost can be high for patients in low-income countries. OBJECTIVE:...

journal_title：Respiratory medicine

authors： Schor D,Rizzo JÂ,Medeiros D,Dela Bianca AC,Silva AR,Nunes C,Morais-Almeida M,Sarinho E

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Although theophylline has been shown to have anti-inflammatory effects, the therapeutic use of theophylline before sepsis is unknown. The aim of our study was to determine the effect of theophylline on COPD patients presenting with sepsis. METHODS:This nationwide, population-based, propensity score-matched ...

journal_title：Respiratory medicine

authors： Shih YN,Chen YT,Chu H,Shih CJ,Ou SM,Hsu YT,Chen RC,Quraishi SA,Aisiku IP,Seethala RR,Frendl G,Hou PC

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Although FEV1/FVC ratio has been shown to be negatively associated with longer duration of asthma; an association between RV/TLC ratio and longer duration of asthma has not been explored. MATERIAL AND METHODS:Patients with established asthma for more than a year and met inclusion and exclusion criteria were...

journal_title：Respiratory medicine

authors： Tiwari A,Rahman K,Abejie B,Jain VV,Vempilly JJ

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Severe asthma is a heterogeneous disease. Patients with both eosinophilic and allergic asthma phenotypes may be eligible for treatment with mepolizumab and omalizumab. Evidence on the relative effectiveness of these treatments in this 'overlap' population would be informative for clinical and payer decision ...

journal_title：Respiratory medicine

authors： Cockle SM,Stynes G,Gunsoy NB,Parks D,Alfonso-Cristancho R,Wex J,Bradford ES,Albers FC,Willson J

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:to describe the clinical manifestations and survival of patients with ILD and myositis-specific and associated autoantibodies, and to evaluate the performance of the new ATS/ERS classification criteria for IPAF. PATIENTS AND METHODS:Patients with ILD and positive in at least one of the following autoantibodi...

journal_title：Respiratory medicine

authors： Mejía M,Herrera-Bringas D,Pérez-Román DI,Rivero H,Mateos-Toledo H,Castorena-García P,Figueroa JE,Rojas-Serrano J

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Dysregulation of the prostaglandin E2 (PGE2) signaling pathway has been implicated in interstitial pneumonia (IP) pathogenesis. Due to the unstable nature of PGE2, available detection methods may not precisely reflect PGE2 levels. We explored the clinical usefulness of measuring stable prostaglandin E-major ...

journal_title：Respiratory medicine

authors： Horikiri T,Hara H,Saito N,Araya J,Takasaka N,Utsumi H,Yanagisawa H,Hashimoto M,Yoshii Y,Wakui H,Minagawa S,Ishikawa T,Shimizu K,Numata T,Arihiro S,Kaneko Y,Nakayama K,Matsuura T,Matsuura M,Fujiwara M,Okayasu I,I

更新日期：2017-01-01 00:00:00

abstract：:Pulmonary hypertension (PH) is a chronic cardiopulmonary disorder that if left untreated, progresses rapidly and is ultimately fatal. The World Health Organization (WHO) has classified PH into 5 distinct groups according to pathophysiology, hemodynamic characteristics, and clinical presentation. Dysfunction in the nit...

journal_title：Respiratory medicine

authors： Benza R,Mathai S,Nathan SD

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Almost all international guidelines recommend corticosteroids for management of exacerbations of chronic obstructive pulmonary disease (COPD), because it leads to improved outcomes of acute exacerbations of chronic obstructive pulmonary disease (AECOPD). Nevertheless, due to its side effects, there are still...

journal_title：Respiratory medicine

authors： Ding Z,Li X,Lu Y,Rong G,Yang R,Zhang R,Wang G,Wei X,Ye Y,Qian Z,Liu H,Zhu D,Zhou R,Zhu K,Ni R,Xia K,Luo N,Pei C

更新日期：2016-12-01 00:00:00

abstract：:Antifibrotic drugs for idiopathic pulmonary fibrosis patients in England and Scotland are only available to those with FVC percent predicted (FVC%pred) less than or equal to 80%. The prescribing guidance does not state which set of reference values should be used and we show that a patient's FVC%pred can change by 4-6...

journal_title：Respiratory medicine

authors： Ward K,Spurr L,Goldman NR,Margaritopoulos GA,Kokosi M,Renzoni E,Chua F,Maher TM,Ward S,Wells AU

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Smoking and obesity might alter the risk of sarcoidosis. However, the data remained inconclusive. METHODS:A cohort of Olmsted County, Minnesota residents diagnosed with sarcoidosis between January 1, 1976 and December 31, 2013 was identified based on individual medical record review. For each sarcoidosis su...

journal_title：Respiratory medicine

authors： Ungprasert P,Crowson CS,Matteson EL

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:The development of pulmonary hypertension (PH) and its effect on long-term survival in bronchiectasis subjects has not been explored. The present study aims to analyze the factors associated with PH and its effect on long-term survival in bronchiectasis subjects. METHODS:We prospectively evaluated 23 bronch...

journal_title：Respiratory medicine

authors： Öcal S,Portakal O,Öcal A,Demir AU,Topeli A,Çöplü L

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:The histologic diagnosis of Pulmonary Langerhans cell histiocytosis (PLCH) is invasive and can cause complications. To confirm the diagnosis of PLCH, guidelines therefore recommend measuring CD1a-positive bronchoalveolar lavage fluid (BALF) cells despite its poor sensitivity and specificity. Thus, an improve...

journal_title：Respiratory medicine

authors： Lommatzsch M,Bratke K,Stoll P,Mülleneisen N,Prall F,Bier A,Virchow JC

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:We investigated the real-world effectiveness of several drugs (including short- and long-acting beta-agonists [SABAs and LABAs], inhaled corticosteroids [ICS], and antibiotics) in preventing severe asthma exacerbations by carrying-out a large observational study based on the healthcare utilization databases o...

journal_title：Respiratory medicine

authors： Arfè A,Blasi F,Merlino L,Corrao G

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Asthma in the elderly as well as asthma of adult-onset has been associated with increased morbidity, but little is known specifically about the effects of age on clinical and inflammatory outcomes in severe refractory asthma. The aims of the study were to examine the effects of age [<65 versus ≥65 years] and...

journal_title：Respiratory medicine

authors： Chaudhuri R,McSharry C,Heaney LG,Niven R,Brightling CE,Menzies-Gow AN,Bucknall C,Mansur AH,Lee W,Shepherd M,Spears M,Cowan DC,Husi H,Thomson NC,BTS Severe Asthma Network.

更新日期：2016-09-01 00:00:00

abstract：:Asthma progression is associated with airway remodeling and neo-vascularization. However, role of angiogenesis in these changes remains unclear and available data still incomplete. In this pilot study we verify usefulness of proteome profiler assay in screening of angiogenesis-related factors in exhaled breath condens...

journal_title：Respiratory medicine

authors： Grzela K,Litwiniuk M,Krejner A,Zagorska W,Grzela T

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:We hypothesized that increased pulmonary vascular permeability may play a role in the pathogenesis of an acute exacerbation of the idiopathic interstitial pneumonias (AE-IIPs). Angiopoietin-2 (Ang-2) promotes endothelial activation, destabilization, and inflammation. The purpose of this study w...

journal_title：Respiratory medicine

authors： Ando M,Miyazaki E,Abe T,Ehara C,Goto A,Masuda T,Nishio S,Fujisaki H,Yamasue M,Ishii T,Mukai Y,Ito T,Nureki SI,Kumamoto T,Kadota J

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Stepping down from combination asthma therapy (inhaled corticosteroids (ICS) + long-acting β2 agonists (LABA)) is often avoided due to fear of exacerbations, which may lead to overmedication in well-controlled asthma. A better knowledge about the predictors of outcome might encourage clinicians to start step...

journal_title：Respiratory medicine

authors： Koskela HO,Purokivi MK,Kokkarinen J

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:An Expert Forum was held at the 2014 European Respiratory Society International Congress to address issues involved in the management of Pseudomonas aeruginosa infection in patients with non-cystic fibrosis bronchiectasis (NCFB). Multiple studies have found that chronic P. aeruginosa infection is associated ...

journal_title：Respiratory medicine

authors： Wilson R,Aksamit T,Aliberti S,De Soyza A,Elborn JS,Goeminne P,Hill AT,Menendez R,Polverino E

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Bleach is widely used for household cleaning. Although it is recognized that occupational use of bleach may have adverse respiratory health effects, it is unknown whether common domestic use of bleach may be a risk factor for asthma. AIM:To assess whether the domestic use of bleach for home cleaning is asso...

journal_title：Respiratory medicine

authors： Matulonga B,Rava M,Siroux V,Bernard A,Dumas O,Pin I,Zock JP,Nadif R,Leynaert B,Le Moual N

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Sarcoidosis patients often are troubled by dyspnea, exercise limitation, and fatigue. Many patients (up to 50-81%) suffer from sarcoidosis-associated fatigue. The etiology of fatigue in sarcoidosis is still unclear. OBJECTIVE:The aim of this study was to assess the relationship between fatigue and both exer...

journal_title：Respiratory medicine

authors： Strookappe B,De Vries J,Elfferich M,Kuijpers P,Knevel T,Drent M

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Many patients with DMD undergo tracheostomy. Tracheostomy is associated with certain complications, however its effect on prognosis is not known. METHODS:The relationship between type of mechanical ventilation and survival at 12 years was evaluated in a prospective cohort of patients with Duchenne muscular ...

journal_title：Respiratory medicine

authors： Boussaïd G,Lofaso F,Santos DB,Vaugier I,Pottier S,Prigent H,Bahrami S,Orlikowski D

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Neurocognitive impairment has been described in COPD patients, but little is known about its relationship with physical functioning and health-related quality of life (HRQL) in this chronically ill patient group. METHODS:301 stable COPD patients completed the Trail Making Test (TMT-A: psychomotor speed and ...

journal_title：Respiratory medicine

authors： Schure MB,Borson S,Nguyen HQ,Trittschuh EH,Thielke SM,Pike KC,Adams SG,Fan VS

更新日期：2016-05-01 00:00:00